CALL FOR PAPERS MICCAI 2010 Workshop on Statistical Atlases and Computational Models of the Heart: Mapping Structure and Function + a Cardiac Electrophysiological Simulation Challenge! Beijing, China (in conjonction with MICCAI'10) WEBSITE: KEYNOTE SPEAKERS * Leon Axel, New York University, USA * Alejandro Frangi, Universitat Pompeu Fabra, Barcelona, Spain * Razvan Ionasec, Siemens Corporate Research, Princeton, USA * Hervé Delingette, INRIA Sophia-Antipolis, France * Dimitris Metaxas, Rutgers, New York, USA * Daniel Rueckert, Imperial College London, United Kingdom * Cristian Lorenz, Philips, Hamburg, Germany TOPIC There has been considerable progress over the last years in the construction and application of cardiac atlases and computational models which integrate heart shape, function and physiology, as illustrated for instance by the "Physiome project" and the “Virtual Physiological Human” European initiatives. Integrative models of cardiac function are important for understanding disease, evaluating treatment, and planning intervention. Noninvasive cardiovascular imaging plays an important role in defining the computational domain, the boundary/initial conditions, and tissue function and properties. Hence, one of the currently most important challenges in the field is the development of robust and effective parameterization and personalization of these computational models with only minimally-invasive clinical imaging. However, in order to evaluate the model output and achieve clinical impact, such personalised models have to be compared with generic knowledge on the healthy and pathological heart. This knowledge can be acquired through the building of statistical models of the heart. Several efforts are now established to provide web-accessible structural and functional atlases of the normal and pathological heart for clinical, research and educational purposes. Ontological schemata are then required to describe input and output in machine readable form. We believe all these approaches will only be effectively developed through collaboration across the full research scope of the imaging and modelling communities. This workshop will provide a forum for the discussion of the latest developments in the areas of heart mapping, including atlas construction, statistical modeling of cardiac function across patient groups, cardiac computational physiology, model personalization, ontological schemata for data and results, atlas based functional analysis, integrated functional/structural analyses but also experts in cardiology, radiology, biology and physiology. Through this workshop we would also particularly like to engage a new generation of early career researchers in working at this interface. SIMULATION CHALLENGE A simulation challenge will be included in this workshop. The goal of this challenge is to compare strategies for the personalisation of different cardiac computational models with experimental data. A complete dataset will be provided in advance, so that all submissions can use it. This dataset will contain the cardiac geometry and fibre orientations from MRI as well as epicardial transmembrane potential from optical mapping. Participants will submit personalised models and resulting isochrones, in order to allow a discussion on the different personalisation strategies and results. Predictions of the personalised models will be also tested with additional data, made available between the submission time and the workshop time. SCOPE 1. Efficient and robust statistical representations of cardiac morphology and morphodynamics 2. Atlas-based quantitative analysis of cardiac images 3. Atlas construction methods. 4. Sharing and reuse of computational cardiac anatomical, mechanical and electrophysiological models 5. Strategies for the personalization of cardiac computational models 6. Parameter sensitivity quantification and identification of relevant parameters in complex computational models 7. Integration of multimodal data in a common reference space 8. Clinical translation of imaging and modeling techniques 9. Statistical analysis of regional heart shape and wall motion characteristics across population groups. 10. Ontological schema to facilitate computational grid infrastructure. 11. Atlas-based physiological analysis of subject-specific characteristics. KEY DATES 8 June - Deadline for workshop paper submission. 13 July - Paper acceptance notification. 24 July - Draft program to MICCAI2010 organizers. 15 Aug - Final program to MICCAI2010. 20 Sept – All day workshop in Beijing. JOURNAL SPECIAL EDITION A review journal paper with all the simulation challenge participants is planned in order to present the different personalization strategies. We also discussed with the editor in chief of Medical Image Analysis a special issue of this journal on the topic of the workshop, where the authors of the best papers will be invited to submit full peer-reviewed articles and his response was extremely positive. ORGANIZERS * Dr. Oscar Cámara. Center for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain * Mihaela Pop, Sunnybrook Health Sciences Centre, University of Toronto, Canada * Dr. Kawal Rhode, Division of Imaging Sciences, St Thomas' Hospital, King’s College London, United Kingdom * Dr. Maxime Sermesant, Asclepios team, INRIA, Sophia Antipolis, France * Pr. Nicolas Smith, Computing Laboratory, St John's College, University of Oxford, United Kingdom * Dr. Alistair Young, Department of Anatomy with Radiology, Auckland MRI Research Group, Auckland Bioengineering Institute, University of Auckland, New Zealand